Pubblicato
nuovo studio scientifico che rivela un incremento significativo del rischio di
mortalità per leucemia mieloide in soggetti esposti (per motivi lavorativi) a
campi magnetici a bassa frequenza (come quelli emessi ad esempio dagli
elettrodotti).
Nelle conclusioni si evidenzia come le analisi eseguite non
hanno fornito prove convincenti di un aumento del rischio di morte per una
serie di tumori ematolinfopoietici in lavoratori esposti a livelli magnetici
ELF di livello medio o alto ma hanno rilevato un aumento del rischio di
leucemia mieloide acuta in lavoratori esposti a livelli elevati e che i rischi osservati
sono in linea con le precedenti relazioni meta-analisi sull'esposizione ELF-MF.
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Occupational extremely low frequency magnetic
fields (ELF-MF) exposure and hematolymphopoietic cancers - Swiss National
Cohort analysis and updated meta-analysis.
Author
information
- Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands; Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland. Electronic address: a.huss@uu.nl.
- Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland.
- Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland; School of Social and Community Medicine, University of Bristol, United Kingdom.
- Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands.
- Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands; Julius Centre for Public Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands.
ABSTRACT
PURPOSE:
Previous studies have examined risks of leukaemia and selected lymphoid
malignancies in workers exposed to extremely low frequency magnetic fields
(ELF-MF). Most studies evaluated hematolymphopoietic malignancies as a combined
category, but some analyses suggested that effects may be contained to some
specific leukaemia or lymphoma subtypes, with inconsistent results.
METHODS:
We examined exposure to ELF-MF and mortality 1990-2008 from different types
of hematolymphopoietic cancers in the Swiss National Cohort, using a job
exposure matrix for occupations recorded at censuses 1990 and 2000. We analysed
3.1 million workers exposed at different levels to ELF-MF: ever-high,
only-medium, only-low exposure using Cox proportional hazard models. We
evaluated risk of death from acute myeloid leukaemia (AML), chronic myeloid
leukaemia, lymphoid leukaemia, diffuse large B-cell lymphomas, follicular
lymphoma, Waldenström's macroglobulinemia, multiple myeloma and Hodgkin
lymphoma.
RESULTS:
Mortality from hematolymphopoietic cancers was not associated with exposure
to ELF-MF with the exception of an increase in ever-high exposed men of myeloid
leukaemias (HR 1.31, 95% CI 1.02-1.67), and AML (HR 1.26, 95%CI 0.93-1.70). If
workers had been high exposed during their vocational training and at both
censuses, these HR increased to 2.24 (95%CI 0.91-5.53) and 2.75 (95%CI
1.11-6.83), respectively.
CONCLUSIONS:
Our analysis provided no convincing evidence for an increased risk of death
from a range of hematolymphopoietic cancers in workers exposed to high or
medium levels of ELF magnetic fields. However, we observed an increased risk of
acute myeloid leukaemia in workers exposed to high levels for a longer
duration. Observed risks are in line with meta-analysed previous reports on ELF-MF
exposure and AML risk, with a summary relative risk of 1.21 (95%CI 1.08-1.37).
FONTE:
NCBI- The National Center for Biotechnology Information
