NELLO STUDIO " INTEROCC " SI RILEVA CHE L'ESPOSIZIONE PROFESSIONALE A CAMPI MAGNETICI A FREQUENZA ESTREMAMENTE BASSA E' ASSOCIATA A RISCHI DI TUMORE CEREBRALE

1. 1. 1. OCCUPATIONAL EXPOSURE TO EXTREMELY LOW FREQUENCY MAGNETIC FIELDS AND BRAIN TUMOUR RISKS IN THE INTEROCC STUDY

2. 1. Michelle C. Turner1,*, 
   2. Geza Benke2, 
   3. Joseph D. Bowman3, 
   4. Jordi Figuerola4,
   5. Sarah Fleming5, 
   6. Martine Hours6, 
   7. Laurel Kincl7, 
   8. Daniel Krewski8, 
   9. Dave McLean9,
   10. Marie-Elise Parent10, 
   11. Lesley Richardson11, 
   12. Siegal Sadetzki12, 
   13. Klaus Schlaefer13,
   14. Brigitte Schlehofer13, 
   15. Joachim Schuz14, 
   16. Jack Siemiatycki15,
   17. Martie Van Tongeren16, and 
   18. Elisabeth Cardis4

+Author Affiliations

1. ¹Parc de Recerca Biomèdica de Barcelona, Doctor Aiguader, 88, Centre for Research in Environmental Epidemiology
2. ²Monash University
3. ³National Institute for Occupational Safety and Health
4. ⁴Centre for Research in Environmental Epidemiology
5. ⁵University of Leeds
6. ⁶Unité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR
7. ⁷Oregon State University
8. ⁸McLaughlin Centre for Population Health Risk Assessment, University of Ottawa
9. ⁹Massey University
10. ¹⁰INRS-Institut Armand-Frappier, University of Quebec
11. ¹¹Hospital Research Centre, University of Montreal
12. ¹²The Cancer & Radiation Epidemiology Unit, The Gertner Institute
13. ¹³Unit of Environmental Epidemiology, German Cancer Research Center
14. ¹⁴Section of Environment and Radiation, International Agency for Research on Cancer (IARC)
15. ¹⁵Hospital Research Center, University of Montreal
16. ¹⁶Exposure Assessment, Institute of Occupational Medicine

1. ↵* Corresponding Author:

2. Michelle C. Turner, Parc de Recerca Biomèdica de Barcelona, Doctor Aiguader, 88, Centre for Research in Environmental Epidemiology, Barcelona, 08003, Spainmturner@creal.cat

Abstract

Background: Occupational exposure to extremely low frequency magnetic fields (ELF) is a suspected risk factor for brain tumours, however the literature is inconsistent. Few studies have assessed whether ELF in different time windows of exposure may be associated with specific histologic types of brain tumours. This study examines the association between ELF and brain tumours in the large-scale INTEROCC study. Methods: Cases of adult primary glioma and meningioma were recruited in seven countries (Australia, Canada, France, Germany, Israel, New Zealand, United Kingdom) between 2000 and 2004. Estimates of mean workday ELF exposure based on a job exposure matrix assigned. Estimates of cumulative exposure, average exposure, maximum exposure, and exposure duration were calculated for the lifetime, and 1-4, 5-9, and 10+ years prior to the diagnosis/reference date. Results: There were 3,761 included brain tumour cases (1,939 glioma, 1,822 meningioma) and 5,404 population controls. There was no association between lifetime cumulative ELF exposure and glioma or meningioma risk. However, there were positive associations between cumulative ELF 1-4 years prior to the diagnosis/reference date and glioma (odds ratio (OR) ≥ 90th percentile vs < 25th percentile = 1.67, 95% confidence interval (CI) 1.36-2.07, p < 0.0001 linear trend), and, somewhat weaker associations with meningioma (OR ≥ 90th percentile vs < 25th percentile = 1.23, 95% CI 0.97-1.57, p = 0.02 linear trend). 

Conclusions: Results showed positive associations between ELF in the recent past and glioma. Impact: Occupational ELF exposure may play a role in the later stages (promotion and progression) of brain tumourigenesis.

• Received January 30, 2014.
• Revision received June 2, 2014.
• Accepted June 4, 2014.

FONTE : http://cebp.aacrjournals.org/content/early/2014/06/14/1055-9965.EPI-14-0102.abstract