Nelle conclusioni si evidenzia come l’esposizione a EMF , esposizione a
campi elettromagnetici emessi da un telefono cellulare GSM utilizzato da donne
in stato di gravidanza, può causare effetti negativi sulla proliferazione
cellulare e lo sviluppo del sistema nervoso in embrioni precoci.
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Proteomic analysis on the
alteration of protein expression in the early-stage placental villous tissue of
electromagnetic fields associated with cell phone exposure.
1Department of Reproductive Endocrinology,
Women's Hospital, Zhejiang University School of Medicine, Ministry of Education
Key Laboratory of Reproductive Genetic, Women's Reproductive Health Laboratory,
Hangzhou, China.
Abstract
BACKGROUND:
To explore the possible adverse effects and search for cell phone
electromagnetic field (EMF)-responsive proteins in human early reproduction, a
proteomics approach was employed to investigate the changes in protein
expression profile induced by cell phone EMF in human chorionic tissues of
early pregnancy in vivo.
METHODS:
Volunteer women about 50 days pregnant were exposed to EMF at the
average absorption rate of 1.6 to 8.8 W/kg for 1 hour with the irradiation
device placed 10 cm away from the umbilicus at the midline of the abdomen. The
changes in protein profile were examined using 2-dimensional electrophoresis
(2-DE).
RESULTS:
Up to 15 spots have yielded significant change at least 2- to
2.5-folds up or down compared to sham-exposed group. Twelve proteins were
identified- procollagen-proline, eukaryotic translation elongation factor 1
delta, chain D crystal structure of human vitamin D-binding protein,
thioredoxin-like 3, capping protein, isocitrate dehydrogenase 3 alpha,
calumenin, Catechol-O-methyltransferase protein, proteinase inhibitor 6 (PI-6;
SerpinB6) protein, 3,2-trans-enoyl-CoA isomerase protein, chain B human
erythrocyte 2,3-bisphosphoglycerate mutase, and nucleoprotein.
CONCLUSION:
Cell phone EMF might alter the protein profile of chorionic tissue
of early pregnancy, during the most sensitive stage of the embryos. The
exposure to EMF may cause adverse effects on cell proliferation and development
of nervous system in early embryos. Furthermore, 2-DE coupled with mass
spectrometry is a promising approach to elucidate the effects and search for
new biomarkers for environmental toxic effects.
FONTE : http://www.ncbi.nlm.nih.gov/pubmed/23420827
